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All genotoxicity tests performed on metoprolol tartrate a dominant lethal study in mice, chromosome studies in somatic cells, a salmonella mammalian -microsome mutagenicity test, and a nucleus anomaly test in somatic interphase nuclei and metoprolol succinate a salmonella mammalian -microsome mutagenicity test were negative.

For example, the loop di- extracellular fluid volume uretic drugs furosemide, bumetanide inhibit the na-k- or eabv 2cl cotransporter in the thick ascending limb, the thiazide diuretics inhibit the na-cl cotransporter in the distal con- sensor voluted tubule, and amiloride blocks the epithelial na renal channel in the collecting ducts see chapter 23 .